Paper Title
Mapping Morphological Changes of the Hippocampus in Alzheimer’s Disease and Normal Aging
Abstract
Histological studies have suggested differing involvement of the hippocampus morphological changes in ageing
and in Alzheimer’s disease (AD). The aim of this study was to assess in vivo local hippocampus changes in Alzheimer’s
disease and ageing Alzheimer’s disease based on 1.5 Tesla brain magnetic resonance images (MRI). MRI is an important
imaging biomarker in AD as the cerebral atrophy has been shown to strongly associate with cognitive symptoms. The decrease
of volume estimates in different structures of the medial temporal lobe related to memory correlates with the decline of
cognitive functions in neurodegenerative diseases. Special effort has been dedicated to separate AD and mild cognitive
impairment (MCI) related modifications from normal aging for the purpose of early detection and prediction. We analyzed
baseline MR imaging data from 48 subjects from the Alzheimer’s Disease Neuroimaging Initiative-1 (ADNI-1) T1- weighted
images were acquired 12 with Alzheimer disease, 12 with mild cognitive impairment, 12 with normal aging and 12 young
healthy controls. We analyzed the effect of normal ageing and in Alzheimer’s disease on hippocampus based on radial distance
mapping.
Index Terms - Alzheimer’s disease, mild cognitive impairment, magnetic resonance images, hippocampus,
neurodegenerative diseases