Implantable Telemetry System In A Multiple Stress Animal Model For Evaluation Of Anti-Stress And Adaptogenic Activity
The use of telemetry sensors for physiological measurements has once again established the role of
Electronics in the field of Biology. This study presents radiotelemetry as a ‘State of the art’ technology that
could perform measurements in the conditions that have been previously made possible only with the help of
rectal probes that work on the principle of thermocouple thermo junction. Different animal models have been
developed to examine endurance promotion and stress tolerance of substances of various origins. Cold-Hypoxia-
Restraint multiple stress animal model (CHR) has been designed and developed in our own laboratory that uses
fall in core body temperature from 37C to 22C as a measure of endurance towards multiple stresses. Herbal
formulation which is to be tested for its adaptogenic activity is orally administered to the animal prior CHR
exposure. With the improvisation of CHR using radiotelemetry we could circumvent the use of tethered animals.
Radiotelemetry came as a savior for the existing system, as the results are found to be more precise,
reproducible and useful in cross-over studies where the use of animals are ethically restricted. Radiotelemetry
system can also be employed for measuring blood pressures and ECG under CHR conditions. These parameters
would strengthen the physiological aspects of the studies and would further aid in developing herbal formulation
as a pharmaceutical.
Keyword - Cold-Hypoxia-Restraint (CHR), Adaptogen, Radiotelemetry.