Paper Title :Efficiency of Folate-Decorated Methotrexate Nanoparticles in MCF-7
Author :Ousanee Issarachot, Jiraphong Suksiriworapong, Kittisak Sripha, Mikihisa Takano, Ryoko Yumoto, Varaporn Buraphacheep Junyaprasert
Article Citation :Ousanee Issarachot ,Jiraphong Suksiriworapong ,Kittisak Sripha ,Mikihisa Takano ,Ryoko Yumoto ,Varaporn Buraphacheep Junyaprasert ,
(2017 ) " Efficiency of Folate-Decorated Methotrexate Nanoparticles in MCF-7 " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 77-79,
Volume-5, Issue-4, Spl. Iss-1
Abstract : This study aim to prepare targeted nanoparticles from tri and di-block copolymer of PEGylatedP(CL) and
investigate in vitro study in MCF-7. MTX conjugated copolymers at 10% and subsequently decorated with FOL-conjugated
copolymers at 5 were prepared from PCL-PEG-PCL (tri-block pattern) and mPEG-PCL (di block pattern) via click reaction.
After that, non-targeted and targeted nanoparticle were prepared by dialysis method. Four type of nanoparticles were
investigated their characteristics and cytotoxicity. The results found that the targeted nanoparticles were toxic to MCF-7 than
non-targeted nanoparticles. Moreover, targeted nanoparticles form tri-block pattern were effective than di-block
nanoparticles due to the different formation of nanoparticles.
Keywords - Targeted nanoparticles, methotrexate, folic acid, MCF-7
Type : Research paper
Published : Volume-5, Issue-4, Spl. Iss-1
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-10061
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Copyright: © Institute of Research and Journals
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Published on 2018-01-24 |
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