Paper Title :Phospholipid Formulation for Oral Drug Delivery
Author :Dae-Duk Kim
Article Citation :Dae-Duk Kim ,
(2018 ) " Phospholipid Formulation for Oral Drug Delivery " ,
International Journal of Advances in Science, Engineering and Technology(IJASEAT) ,
pp. 11-13,
Volume-6,Issue-1,Special Issue - 1
Abstract : Novel proliposomes (PLs) with increased lipid content was prepared and characterized in vitro and in vivo. The
solid state PLs were characterized by scanning electron microscopy (SEM), powder X-ray diffractometer (PXRD) and
differential scanning calorimetry (DSC). The liposomes were reconstituted, and particle size, zeta potential , entrapment
efficiency (EE) and drug loading were evaluated. Particle morphology was determined by transmission electron microscopy
(TEM). In vitro dissolution and in vivo pharmacokinetic study of PLs were evaluated comparing with crude drug powder. The
phospholipid content of the PLs was increased up to 20% (w/w) without stickiness. The particle size of reconstituted
liposomes was 580 ± 12 nm. The zeta potential and EE of drug was -64.2 ± 0.3 mV and 78.4 ± 3.6%, respectively. Crystalline
state of drug was transformed to amorphous state by incorporating in PLs. In pharmacokinetic study in rats, PLs showed
shorter Tmax, higher Cmax and AUC, compared with crude drug powder. The amorphous state of the drug in the PLs resulted in
increasing solubility and dissolution rate and extent of the drug incorporated, thereby increasing the oral bioavailability of
drug.
Index Terms - Formulation, Drug delivery, Phospholipid, Bioavailability.
Type : Research paper
Published : Volume-6,Issue-1,Special Issue - 1
DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-11160
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Published on 2018-04-12 |
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