Paper Title :The Effect of Indole-3-Carbinol (I3c) in the Aorta Histopathology of Mice With Atherogenic Diet

Author :Hazmi Dwinanda Nurqistan, Bagus Indra Kusuma, Brenda Desy Romadhon, Silvi Ahmada Chasya, Lusi Padma Sulistianingsih Mata, Erma Sulistyaningsih

Article Citation :Hazmi Dwinanda Nurqistan ,Bagus Indra Kusuma ,Brenda Desy Romadhon ,Silvi Ahmada Chasya ,Lusi Padma Sulistianingsih Mata ,Erma Sulistyaningsih , (1970 ) " The Effect of Indole-3-Carbinol (I3c) in the Aorta Histopathology of Mice With Atherogenic Diet " , International Journal of Advances in Science, Engineering and Technology(IJASEAT) , pp. 147-149,

Abstract : Cardiovascular disease is the number one cause of death in the world 82% of deaths occur in developing countries. The process of retention, oxidation and lipid modification that occurs in atherosclerosis lead to chronic inflammation of the artery wall. Research shows that accelerated deposition of plaques in the body caused by trimethylamine oxide (TMAO). TMAO can increase the accumulation of cholesterol in macrophages that enhances the formation of foam cells in the arterial wall. Flavin Monooxygenase (FMO) can inhibit formation of TMAO. Indole-3-carbinol (I3C) is able to work as a competitive inhibitor of FMO. Treatment of I3C is expected to lower cholesterol levels and reduce the amount of foam cells in mice aorta histopathology picture. The treatment group consist of a control, negative control, group A (10 mg/kg I3C), group B (200 mg/kg I3C), and group C (500 mg/kg I3C). Mice was induced by atherogenic diet. Blood cholesterol levels were count and aortic arch mice were taken for histopathological. The blood cholesterol levels in mice induced atherosclerosis decrease and histopaology aorta of mice show decreasing amount of foam cell (p<0,05). Keywords— Atherosclerosis, Indole-3-Carbinol.

Type : Research paper

Published :

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